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Most Anti-Infective Guidelines Don’t Get No Respect (Let Alone Use!)

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It is no secret that most existing antibiotic guidelines are not getting much use these days.  The only indications pursued with any regularity are the feasible ones: ABSSSI, cUTI, and cIAI, much less CABP.  Yes, the occasional HABP/VABP trial is being undertaken by the intrepid but no company has taken Continue reading Most Anti-Infective Guidelines Don’t Get No Respect (Let Alone Use!)→

The Beauty of Science: No Need to Think About Costs When You Live in An Ivory Tower

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The recently published INSIGHT trial showed that starting HIV therapy earlier rather than later has benefit for patients 1. This should not come as a surprise considering the excellent suppressive power of current triple regimens.  The trial which enrolled 4685 HIV infected patients was stopped prematurely when an interim analysis Continue reading The Beauty of Science: No Need to Think About Costs When You Live in An Ivory Tower→

The Etiology of CAP Remains Elusive – A Call to Change Antibiotic Prescribing Patterns

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Once upon a time – not so long ago – we were taught the following: Streptococcus pneumoniae was the cause of 90% of CAP cases. That statement was later modified to mean S. pneumoniae was the underlying pathogen in 90% of bacterial cases of CAP, i.e., those with positive cultures from sputum or Continue reading The Etiology of CAP Remains Elusive – A Call to Change Antibiotic Prescribing Patterns→