Home » aspergillus » Page 2

Tag Archives: aspergillus

Antibiotic Inhalers Galore (Part 1):  More Combinations and Permutations than a Rubik’s Cube

Posted on by — No Comments ↓

There is much interest in inhaled antibiotics these days.  Prima facie, the logic for this approach is compelling: Getting the antibiotic (and a lot of it) directly to the site of infection, while avoiding systemic toxicity, sounds like optimized efficacy plus optimized safety combined.  However, some high-profile failures were published Continue reading Antibiotic Inhalers Galore (Part 1):  More Combinations and Permutations than a Rubik’s Cube→

Two New Antifungals Presented at ICAAC San Diego

Posted on by — No Comments ↓

As noticed by many other colleagues, ICAAC 2015 was a shadow of its former self.  Few participants overall, fewer posters, and even fewer exhibitors.  Reviewing the posters, there were relatively few from industry, most came from university or small research labs.  In a way, ICAAC 2015 was a true reflection of Continue reading Two New Antifungals Presented at ICAAC San Diego→

Cresemba / Isavuconazole:  Not Just Another Azole

Posted on by — No Comments ↓

It is amazing how modifications to the azole structure have produced ever more potent, ever more useful antifungals.  Ketoconazole had limited usability because of its many side effects related to off-target sterol synthesis inhibition, solubility (or lack thereof) and erratic absorption.  Solublity was also an issue for itraconazole and posaconazole.  Continue reading Cresemba / Isavuconazole:  Not Just Another Azole→