Allphase Pharma Consulting, LLC
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A recent article on “Agents that Prevent Biofilm Formation” captured my interest[1]. The authors reviewed the literature and mentioned many substances which have shown in-vitro efficacy in disrupting biofilm production by the main offenders, i.e., S. aureus, S. epidermidis, P. Continue reading Clinical Biofilm Studies – An Interesting Evolving Landscape
It is no secret that most existing antibiotic guidelines are not getting much use these days. The only indications pursued with any regularity are the feasible ones: ABSSSI, cUTI, and cIAI, much less CABP. Yes, the occasional HABP/VABP trial is Continue reading Most Anti-Infective Guidelines Don’t Get No Respect (Let Alone Use!)
Several reasons have been proposed as explanations why so many S. aureus vaccines have failed in clinical trials. Clearly, the organism has a battery of virulence factors which may require a multipronged approach and neutralizing just a single mechanism with a specific mAb Continue reading Learning from Set-Backs: The Frustrating Search for a Staphylococcal Vaccine