Besides ceftriaxone (CTRIAX), cefixime and spectinomycin we have no other highly effective single-dose treatment regimens for urogenital GC. Failures of all 3 drugs have been described but remain rare, can be overcome with higher doses of CTRIAX (1 g instead
Continue reading GC Therapy – Shooting for the Stars → Like this: Like Loading...
Posted in QIDP Antibiotics, Recent Literature, The News, The Viewpoint |
Tagged antibiotic blog, azithromycin, Baxdela, CDC, cefixime, ceftriaxone, Cempra, delafloxacin, Entasis, ETS-XXX, ETX-0914, FDA, FDA Guidance for GC, GC, Gepotidacin, gonorrhea, GSK, GSK-2140944, Harald Reinhart, Martin Shkreli, Melinta, PROCEEDING study, repeat dosing for GC, Rocephin, SOLITAIRE-U, Solithera, solithromycin, spectinomycin, STD, Suprax, topoisomerase II inhibitor, Trobicin, WHO, Zithromax, Zoliflodacin |
It is time for a new look at the field of QIDP drugs. Today we are providing an updated searchable database which now has 57 entries. (Status: 10/18/16) Despite best efforts to provide accurate information, errors may have crept in. Please let us
Continue reading QIDP Drug Update – Part 1: An Updated Who Is Who → Like this: Like Loading...
Posted in QIDP Antibiotics, The News |
Tagged Achaogen, Actelion, AeroVanc, Allergan, antibiotic blog, antibiotic development, Aradigm, Avycaz, Basilea, Baxdela, Bayer, Brilacidin, Cadazolid, Cardeas, Ceftazidime/avibactam, Cellceutix, Cempra, Cidara, Citius, CorMedix, Dalvance, daptomycin, Debiopharm Pharmaceuticals, delafloxacin, Destiny, Entasis, eravacycline, FDA, fosfomycin, Fusidic Acid, GSK, Harald Reinhart, iclaprim, Innocoll, Insmed, Ixodes, Matinas, Meiji Seika Pharma, Melinta, Merck, MGB Biopharma, Microbion, Morphochem, Motif Bio, Nabriva, Nemonoxacin, neutrolin, omadacycline, oritavancin, Paratek, plazomicin, Polyphor, QIDP, QIDP list of antibiotics, Raptor, RedHill Biopharma, Savara, Scynexis, Sivextro, Solithera, solithromycin, SPA, special protocol assessmentn, Summit, Surotomycin, Symbiomix, TaiGen, tedizolid, Tetraphase, The Medicines Company, Valley Fever Solutions, Viamet, Vical, Wockhardt, Zavante, Zinforo |
At first glance, the list of features that distinguish AZD-0914 from other FQ seems impressive: broad Gram-positive and Gram-negative activity, MRSA and MSSA activity, potency against fluoroquinolone (FQ)-resistant isolates, low frequency for S. aureus resistance, and impressive activity against C.
Continue reading AZD-0914: A New Broad-Spectrum Narrow-Development Path Drug → Like this: Like Loading...
Posted in QIDP Antibiotics, The News, The Viewpoint |
Tagged ABSSSI, Achaogen, anti-staphylococcal monoclonal antibody, antibiotic blog, AstraZeneca, AZD-0914, CABP, delafloxacin, Entasis, eravacycline, ETX-0914, FoM, frequency of mutation, GC, gepoticidin, GSK, GSK-2140944, gyrase inhibitor, Harald Reinhart, MEDI-4893, MedImmune, Melinta, MoA, MRSA, MSSA, N. gonorrhoeae, plazomicin, QIDP, Tetraphase, topoisomerase II inhibitor, VABP, VABP prophylaxis, Zoliflodacin |
In the last decade (2000-2010), we saw the number of new antibiotic approvals drop successively each year; FDA changed the rules of the approval process without providing public guidance; many antibiotic companies fled the therapeutic area; investments were redirected to
Continue reading The 10 x ’20 Goal – Are We On Track? → Like this: Like Loading...
Posted in The News, The Viewpoint |
Tagged Allphase Pharma Consulting, antibiotic blog, antibiotic pipeline, AstraZeneca, Avycaz, aztreonam/avibactam, Basilea, Bayer, bedaquiline, ceftaroline, Ceftazidime/avibactam, ceftolozane/tazobactam, dalbavancin, Dalvance, defensin, delafloxacin, Dificid, eravacycline, FabI inhibitor, fidoxamicin, Harald Reinhart, MDR drugs, Merck, omadacycline, Orbactiv, oritavancin, Paratek, Pfizer, POL7080, Polyphor, Roche, Shionogi, Sirturo, Sivextro, tedizolid, televancin, Tetraphase, Vibativ, Zerbaxa, Zinforo |
After the first 100 blogs, it is appropriate to reflect on reader preferences. When I arbitrarily select a topic, it is not always clear whether what interests me also interests you. Since its start 1½ years ago, this blog has grown
Continue reading ALLPHASE PHARMA – THE FIRST 100 BLOG POSTS → Like this: Like Loading...
Posted in Did you know...?, QIDP Antibiotics |
Tagged AIDP, antibiotic blog, Brilacidin, carbavance, ceftolozane, colistin, Cresemba, dalbavancin, Dalvance, delafloxacin, fosfomycin, isavuconazole, Orbactiv, oritavancin, plazomicin, PTK-0796, QIDP list, top 10 |